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Grhl3tm1Jane
Targeted Allele Detail
Summary
Symbol: Grhl3tm1Jane
Name: grainyhead like transcription factor 3; targeted mutation 1, Stephen M Jane
MGI ID: MGI:2684328
Synonyms: Grhl3-
Gene: Grhl3  Location: Chr4:135269199-135300941 bp, - strand  Genetic Position: Chr4, 67.76 cM
Alliance: Grhl3tm1Jane page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86772
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A lacZ reporter gene replaced 2.2 kb of endogenous sequence, including exon 2 which encodes the entire transactivation domain. Northern blot and RT-PCR analysis indicated that the allele represents a null mutation. (J:86772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 125 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grhl3 Mutation:  53 strains or lines available
References
Original:  J:86772 Ting SB, et al., Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med. 2003 Dec;9(12):1513-9
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory